If you look at what happens to people when they get older, their mitochondria become less and less effective. Most disease states have some degree of mitochondrial dysfunction. Certainly that's the case in cancer; certainly that's the case in diabetes; it's the case for a subset of patients with Alzheimer's disease—there's clearly a broken component of metabolism. When the mitochondria go bad, the organism goes bad.
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Impaired Mitochondrial Function is a Hallmark of Aging, Cancer, and Disease
This is coming back. If you consider what happened in 2002 and 2003—if you
basically look at the last 20 years, anybody who thinks we aren't in for lots more coronaviruses in our lifetime fails to appreciate probability theory.
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SARS-CoV-2 Won't Be the Last Coronavirus to Infect Humans
Sleep is probably one of the most potent drivers of immune function. Sleep deprivation renders people susceptible to a downtick in immune function.
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The Four Levers of Optimal Immune System Health: Exercise, Sleep, Nutrition, & Stress
Metformin is a mitochondrial toxin, which is a good thing if your mitochondria are really defective—taking a little bit of a toxicity hit to the mitochondria produces a lot of other benefits. That's why metformin is such a great drug for people with type 2 diabetes. But I question how valuable it is for healthy individuals.
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Peter Stopped Taking Metformin Because It Impairs Zone 2 Exercise
My framework around nutrition is that there are three big levers you can always be pulling with food: dietary restriction, time restriction, and caloric restriction.
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The 3 Nutrition Levers: Dietary, Caloric, and Time Restriction
Most of us are hardwired to want to be right, and when that's where your ego is tethered, you tend to be resistant to information that contradicts your existing views.
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Peter's Medical Philosophy: Strong Convictions, Loosely Held
Where we are today [April 17th, 2020], it's clear to me that the likelihood that this [COVID-19] is going to kill over a million Americans this year is exceedingly low.
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We Now Know COVID-19 Won't Kill More Than 1 Million Americans in 2020
Long-term fasting raises cortisol, which is probably harmful to the immune system short-term.
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Peter Attia & Gwyneth Paltrow Do Fasting While in Quarantine
Recent studies indicate that COVID-19's fatality rate is closer to influenza's than expected.
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COVID-19's Fatality Rate Appears Closer to Influenza's Than Previously Thought
In 2017-2018, we experienced a devastating influenza strain—it probably killed more Americans than this coronavirus will, depending on how this shakes out.
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Your Health Affects How You Recover from Diseases Like COVID-19
Testing & safety profile determination lengthen COVID-19's vaccine development timeline.
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If Reinfected, COVID-19 Survivors Likely Would Only Have Mild Symptoms
